Diabetes Type 1
Update on Worldwide Trends in
Occurrence of Childhood Type 1
Diabetes in 2020
Jaakko Tuomilehto, MD, MA, PhD, FRCP (Edin), Graham D. Ogle, MBBS,
FRACP, Nicolai A. Lund-Blix, MSc, PhD, Lars C Stene, MSc, PhD
Epidemiologic research aims at describing and analysing
the occurrence of a disease, its determinants and its consequences at the population level. Epidemiological
methods can be used for the assessment of the efficacy and effectiveness of preventive interventions, either primary,
secondary or tertiary.
Randomized 52-weekPhase 2 Trial of Albiglutide Versus Placebo in Adult Patients With Newly Diagnosed Type 1 Diabetes
Paolo Pozilli, Emanuele Bosi, Deborah Cirkel, Julia Harris, Nicola Leech, Francisco J. Tinahones, Marie-Christine Vantyghem, Georgios Vlasakakis, Anette-Gabriele Ziegler, and Salim Janmohamed
Context: GLP-1 receptor agonists are an established therapy in patients with type 2 diabetes; however, their role in type 1 diabetes remains to be determined.
Objective: Setermine efficacy and safety of once-weekly albiglutide 30 mg (up-titration to 50 mg at week 6) versus placebo together with insulin in patients with new-onset type-1 diabetes and residual insulin production.
Hypoglycaemia and its management in primary care setting
Mahmoud Ibrahim, Jason Baker, Avivit Cahn, Robert H. Ecke, Nuha Ali El Sayed, Amy Hess Fischl, Peter Gaede, R. David Leslie, Silvia Pieralice, Dario Tuccinardi, Paolo Pozzilli, Bjørn Richelsen, Eytan Roitman, Eberhard Stand, Yoel Toledano, Jaakko Tuomilehto, Sandra L. Weber, Guillermo E. Umpierrez
Hypoglycaemia is common in patients with type 1 diabetes and type 2 diabetes and constitutes a major limiting factor in achieving glycaemic control among people with diabetes. While hypoglycaemia is defined as a blood glucose level under 70 mg/dL
(3.9 mmol/L), symptoms may occur at higher blood glucose levels in individuals with poor glycaemic control.
Hypoglycaemia and its management in primary care setting
Mahmoud Ibrahim, Jason Baker, Avivit Cahn, Robert H. Eckel, Nuha Ali El Sayed, Amy Hess Fischl, Peter Gaede, R. David Leslie, Silvia Pieralice, Dario Tuccinardi, Paolo Pozzilli, Bjørn Richelsen, Eytan Roitman, Eberhard Standl, Yoel Toledano, Jaakko Tuomilehto, Sandra L. Weber, Guillermo E. Umpierrez17
The American Diabetes Association (ADA) defined hypoglycaemia in
diabetes as any episode of an abnormally low plasma glucose concentration that exposes the individual to potential harm.2 This nonnumerical
definition was based on the facts that glycaemic thresholds for responses to hypoglycaemia vary among individuals and within the same individual.
Also, there is no specific glucose concentration that defines hypoglycaemia in diabetes.